Mei Haruna is an effeminate young boy who was raised by his witch mother as a girl and always thought of himself as female. His mother was the only family he had, so after she died, he transfers to an all-girls high school and comes to reside in the school's dormitory with his talking familiar cat Abel, and his roommate Fuuka Honjou, who is also a member of the public morals committee. Shortly after arriving at the school, his new friends discover after a magical display in the dormitory community bath that he is actually male, though this comes as quite a shock to him despite him being aware of the physical differences between him and normal girls. Despite him being found out, and after some helpful intervening of the perverted student council president, the principal of the school decides that he can stay at the school. The next day, Mei comes to school with Fuuka and apologizes for hiding the fact that he was a witch, and informs the others how he is apparently male. The other students quickly accept him as one of their own, and are impressed how he can use magic.

Getting a girlfriend, it's just about the most important thing to a guy when he enters High school. For a fortunate few, all they need to do is look to their right at the familiar face that has always been there smiling and caring. But sadly this isn't the case for our protagonists Meguru and Shou. For starters, they're both guys and on top of that, they haven't had a single female friend since primary school. Perhaps it's their friends showing off the spoils of their romantic pursuits. But something snaps between the childhood friends and each claims they would both be better off if the other was a girl. Though the boys have should have known that you should always be careful of what you wish for. Because that very night, Meguru discovers that he has been turned into a girl! But then, on their first day of school, the two finds themselves surrounded by cute girls. Are the boys regretting what happened? Is this the start of some sort of love triangle? line? cube? some other kind of shape with "love" prepended to it? Or, since Meguru is now a girl, perhaps just a harem for Shou? Either ways, hilarity is guaranteed as Meguru tries his best to adapt to his new life as a girl with his new found friends who are all too oblivious to his condition and too eager to help him get used to his life as a "her".