In the distant past, the prosperous nation of Karma waged war against the nation of Spectra, resulting in the creation of an AI that wiped out all humans. Centuries later, Raye, the last surviving human, lives amongst an android society on the outskirts of Karma. On the night of her 13th birthday, her peaceful life is upended when Spectra attacks, destroying her home and forcing her friends to the front lines. Desperate to save everything she loves, Raye calls upon humanity's last bastion: "Sky Striker", the Karma-developed secret technology made to turn humans into the ultimate living weapons.… Unexpected, right? In this newest adaptation of Yu-Gi-Oh, the focus of the plot is not on the card game, but instead the many storylines featured in the cards. The first arc surrounds the Sky Striker series, with more to come in the future.

The series is set in the near future. Something unexpected happens as Ryoga Kamishiro challenges Yuma Tsukumo to a Duel. When the mysterious entity Astral appears before them, a new legend begins.

Yu☆Gi☆Oh! Arc-V centers around Yuuya Sakaki, a mysterious Entertainment Duelist known as "The Phantom" along with his three other personalities: Yuuto, Yuugo, and Yuuri. He was chased after by Leo Corporation for hacking into their Solid Vision with mass system and used it for his own purpose. While on the run, he meets Yuzu Hiiragi, the daughter of the principal of Syu Zo Duel School that was on the verge of bankruptcy and tricked Yuuya into a contract to become a teacher at her school. However, before Yuuya could teach at the school, he first must find a card called Genesis Omega Dragon that said will determine the fate of the world that also connected to his scattered memories. The story is set in alternate version of Miami City where Leo Corporation, run by its president Reiji Akaba, dominates most of Solid Vision system throughout the city. The spread of the company's Solid Vision with mass not only gave birth to "Action Duels" but also help improving the city in saving lives and repair damage in case of disaster, becoming a vital part of people's life.